epigenetics

Study suggests Roundup’s adverse effects on future generations

/ Nathaniel / 1 Comment

A recent study about rats could have implications for humans. It shows that even when exposure to the herbicide glyphosate (the main active ingredient in Roundup, but also used in other products since the patent US expired in 2000) is low enough not to do evident damage to individual rats, their offspring in the 2nd and 3rd generations may suffer epigenetic effects, meaning that although DNA sequences are not affected, the way the body instructs genes to act may be affected, notably in sperm cells.

Thus, even apart from any effects on the exposed individual humans (witness the recent large court judgments about Bayer-Monsanto), grandchildren and great grand-children may suffer adverse health conditions. Since glyphosate entered the market 43 years ago, children whose grandparents used the product may soon, unfortunately, be observed as test cases.

If this follows the route of tobacco and opioids, after decades of human suffering, government will suddenly find itself “shocked” and start trying to hold companies responsible–with little help for the humans affected, and small impact on the companies’ bottom line or executive leaders.

Below is the official summary of an article in Scientific Reports, volume 9, Article number: 6372 (2019)l read the full article there. See more background on harmful effects of Roundup in “Take Action by September 3 to Ban This Cancer-Causing Weedkiller!” at Organic Consumers Association (accompanying photo is from there).

Assessment of Glyphosate Induced Epigenetic Transgenerational Inheritance of Pathologies and Sperm Epimutations: Generational Toxicology

Abstract

Ancestral environmental exposures to a variety of factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. One of the most widely used agricultural pesticides worldwide is the herbicide glyphosate (N-(phosphonomethyl)glycine), commonly known as Roundup. There are an increasing number of conflicting reports regarding the direct exposure toxicity (risk) of glyphosate, but no rigorous investigations on the generational actions. The current study using a transient exposure of gestating F0 generation female rats found negligible impacts of glyphosate on the directly exposed F0 generation, or F1 generation offspring pathology. In contrast, dramatic increases in pathologies in the F2 generation grand-offspring, and F3 transgenerational great-grand-offspring were observed. The transgenerational pathologies observed include prostate disease, obesity, kidney disease, ovarian disease, and parturition (birth) abnormalities. Epigenetic analysis of the F1, F2 and F3 generation sperm identified differential DNA methylation regions (DMRs). A number of DMR associated genes were identified and previously shown to be involved in pathologies. Therefore, we propose glyphosate can induce the transgenerational inheritance of disease and germline (e.g. sperm) epimutations. Observations suggest the generational toxicology of glyphosate needs to be considered in the disease etiology of future generations.

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Chemical exposure can harm future generations

/ Nathaniel / Leave a comment

This research is a real warning. US testing for harm done by toxic chemicals has long disregarded pregnant women. Recent studies have developed knowledge about epigenetics, the “on-and-off switch” mechanism that adds another layer to Darwin. Fungicides, pesticides, jet fuel, bisphenol A, DEET, atrazine, and as we already knew Roundup: all dangerous to people, and now known dangerous for generations. Rats, mice and pigs are often used as stand-ins for humans in medical testing.

Glyphosate Causes Serious Multi-Generational Health Damage to Rats – New WSU Research , Sustainable Pulse, Apr 23 2019

Michael Skinner, a WSU professor of biological sciences, and his colleagues exposed pregnant rats to the herbicide between their eighth and 14th days of gestation. The dose–half the amount expected to show no adverse effect–produced no apparent ill effects on either the parents or the first generation of offspring.

But writing in the journal Scientific Reports, the researchers say they saw “dramatic increases” in several pathologies affecting the second and third generations. The second generation had “significant increases” in testis, ovary and mammary gland diseases, as well as obesity. In third-generation males, the researchers saw a 30 percent increase in prostate disease – three times that of a control population. The third generation of females had a 40 percent increase in kidney disease, or four times that of the controls.

More than one-third of the second-generation mothers had unsuccessful pregnancies, with most of those affected dying. Two out of five males and females in the third generation were obese.

Skinner and his colleagues call this phenomenon “generational toxicology” and they’ve seen it over the years in fungicides, pesticides, jet fuel, the plastics compound bisphenol A, the insect repellent DEET and the herbicide atrazine. At work are epigenetic changes that turn genes on and off, often because of environmental influences….

read more at Sustainable Pulse